The Welshman, who turns 39 on Thursday, is the only active Premier League player who featured in the opening matches of the competition more than 20 years ago.
Veteran midfielder Giggs said: "I got used to the fact a long time ago that I am playing with someone who wasn't born when I made my debut and all these sort of things that come up.
"So yeah, I have just got used to it. It's something I have got to live with I suppose."
In a question and answer session on the Premier League's official website to mark the milestone of 250million fans being passed, Giggs hailed Manchester United's encounters with Liverpool as his favourite matches and rates former Arsenal full-back Lee Dixon as his toughest opponent.
Giggs added: "I think as a player you want a challenge, so any of the top teams really. I would probably say Liverpool, because there is always such a great build-up.
"It doesn't matter how the teams are doing in the league, there's always that rivalry and there's always that ferocious tempo within the game, whether it be at Old Trafford or Anfield."