The Spaniard was quickly installed in the Stamford Bridge hot-seat on Wednesday night on an interim deal until the end of the season, just hours after Roberto Di Matteo was axed following the club's 3-0 defeat by Juventus in the UEFA Champions League.
Benitez is expected to arrive in England on Thursday morning after cutting short an engagement in the Middle East, and he will have little time in which to prepare his side for Sunday's crucial Premier League home date against Manchester City.
Four league games without a win have seen Chelsea slip four points behind leaders City, while the Champions League holders face elimination at the group stage following a dismal result in Turin.
Benitez will be reunited with Fernando Torres in west London and will be hoping to bring the best out of the struggling striker, who enjoyed a prolific spell while working with him at Liverpool.
The 52-year-old, who is the ninth manager of the Roman Abramovich era, may also have to win over the club's supporters as he was involved in some fiery clashes with Chelsea during his reign at Anfield.
But he must find his feet fast, with London derbies against Fulham and West Ham on the horizon following the top-of-the-table clash with City.