On the back of the successful 2012 Games, the Mayor of London Boris Johnson opened talks with the International Paralympic Committee, UK Athletics and UK Sport over holding the championships in the Olympic Stadium.
If London wins the race for hosting, it would be a double triumph for the city after it beat rival bidder Doha a year ago to host the IAAF World Athletic Championship - to be hosted in August 2017.
Johnson said: "The huge appetite for tickets to the 2012 Games this summer shows the level of excitement Paralympic sport can generate, and forever changed the way we think about disabled sport.
"The 2017 IPC World Championships present a fantastic opportunity for us to build on that phenomenal surge of enthusiasm, and welcome back some of the world's greatest sportsmen and women to the Olympic Stadium.
"Securing the Championships would not only reinforce London's reputation as the world's leading sporting city, it would bring a vital multi-million pound boost to the capital's economy, creating jobs and driving growth in east London."
Two months ago ParalympicsGB bagged 120 medals, including 34 golds, and were third in the medal table behind China and Russia.
Hannah Cockroft, one of GB's greatest stars during the sumer with two track golds in the T34 100m and 200m, tweeted: "Yes! MayorOfLondon has put in a bid to bring the 2017 world championships to London! #bringushome #bringbacklondon"
UK Athletics chairman Ed Warner added: "I'm delighted that the city has decided to build on the success of the Paralympics."